Agent skill · research science · aiskillstore
opentargets-database
Query Open Targets Platform for target-disease associations, drug target discovery, tractability/safety data, genetics/omics evidence, known drugs, for therapeutic target identification.
Why this skill is useful
Provides specific GraphQL API queries and domain-specific knowledge for retrieving target-disease associations and drug information that the AI wouldn't reliably generate on its own.
What it needs
Requires opentargets account access. About 7k tokens when loaded. Last updated 2026-08-07. 405 stars on the source repository.
What this skill does
Open Targets Database Overview The Open Targets Platform is a comprehensive resource for systematic identification and prioritization of potential therapeutic drug targets. It integrates publicly available datasets including human genetics, omics, literature, and chemical data to build and score target-disease associations. Key capabilities: Query target (gene) annotations including tractability, safety, expression Search for disease-target associations with evidence scores Retrieve evidence from multiple data types (genetics, pathways, literature, etc.) Find known drugs for diseases and their mechanisms Access drug information including clinical trial phases and adverse events Evaluate target druggability and therapeutic potential Data access: The platform provides a GraphQL API, web interface, data downloads, and Google BigQuery access. This skill focuses on the GraphQL API for programmatic access. When to Use This Skill This skill should be used when: Target discovery: Finding potential therapeutic targets for a disease Target assessment: Evaluating tractability, safety, and druggability of genes Evidence gathering: Retrieving supporting evidence for target-disease associations Drug repurposing: Identifying existing drugs that could be repurposed for new indications Competitive intelligence: Understanding clinical precedence and drug development landscape Target prioritization: Ranking targets based on genetic evidence and other data types Mechanism research: Investigating biological pathways and gene functions Biomarker discovery: Finding genes differentially expressed in disease Safety assessment: Identifying potential toxicity concerns for drug targets Core Workflow 1. Search for Entities Start by finding the identifiers for targets, diseases, or drugs of interest. …
How to use it
Reference it in AdaL, Claude Code, Cursor or any coding agent — nothing to install:
@skills aiskillstore/opentargets-database